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Brown University

Box G-S121-7

121 South Main Street

Providence, RI 02912

Phone: 401.863.9181

Fax: 401.863.9182

center@stat.brown.edu

 

ACRIN

Biostatistics and Data Management Center of the American College of Radiology Imaging Network (ACRIN)

Faculty: Gatsonis (Director), Blume (Deputy Director), Acharrya, Chen, Gareen, Liu

The American College of Radiology Imaging Network (ACRIN; www.acrin.org) is a cooperative group funded by the Cancer Imaging Program of the National Cancer Institute to conduct multi-center, interdisciplinary clinical evaluations of diagnostic imaging in cancer. ACRIN began its operations in 1999 and is now in its second funding cycle. The Center for Statistical Sciences at Brown is home to the Biostatistics Center of the network. Headquarters and data management operations are based at the Philadelphia Office of the American College of Radiology.

The current research portfolio of ACRIN includes 11 trials in accrual or follow-up, 4 trials in analysis, and 8 trials in development. The network's research program covers all aspects of the role of imaging in cancer, from early detection to diagnosis and staging, to disease management and image guided treatment. The trials vary in size from relatively small studies of developing imaging modalities (such as magnetic resonance imaging spectroscopy) to very large studies of modalities for the early detection of disease. The latter include the Digital Mammography Screening Trial (DMIST), which enrolled 49,500 women and compared the diagnostic accuracy of digital and film mammography, and the National Lung Screening Trial (NLST) which enrolled more than 50,000 participants at high risk for lung cancer and randomized them to annual screening with helical CT or x-ray. More than 100 centers across the US, as well as centers in Canada participate in ACRIN studies.

The Biostatistics Center of ACRIN provides methodologic leadership and support to ACRIN investigators in the design, implementation, and analysis of network studies. Center faculty and staff are integrally involved in every step of the life of each protocol, from the early development of ideas and concept sheets, to the final analysis of the data and the preparation of reports and manuscripts. ACRIN faculty are also engaged in research on statistical methods for the evaluation of the performance of modalities in the early detection and diagnosis of disease and in the prediction of the course of therapy.

Professors Constantine Gatsonis and Jeffrey Blume oversee the operations of the Biostatistics and Data Management Center of ACRIN. Professors Suddho Acharrya, Mei-Hsiu Chen, and Dawei Liu serve as lead statisticians in ACRIN protocols. Professor Ilana Gareen serves as an epidemiologist in several ACRIN studies. Quentin McMullen is the administrative manager of the Biostatistics Center; Jean Cormack, PhD, Lucy Hanna, MS MAT, Ben Herman, SM, Helga Marques, MS, Karthik Meganathan, MS, JoRean Sicks, MS, Brad Snyder, MS, and Jing Zhou, MS are the staff biostatisticians. Nancy Ciminelli, Rebecca McVey, and Cheryl Souza work on the collection of quality of life data in several of the ACRIN studies. Jim Patterson and Henry Robinson provide informatics support for the Biostatistics Center. The Center's administrative personnel includes Diane Deignan, Heather Dominey, and Susan Furtado.

ACRIN Protocols

Open to Accrual / In Follow-up Phase:

  • 6654 - Contemporary Screening for the Detection of Lung Cancer

  • 6657 - MRI in Monitoring Breast Cancer Therapy

  • 6659 - MR Spectroscopy of the Prostate

  • 6660 - Whole Body MRI in the Evaluation of Pediatric Malignancies

  • 6661 - Percutaneous Radiofrequency Ablation of Bone Metastases Using CT Guidance

  • 6664 - National CT Colonography Trial

  • 6665 - A Phase II Trial of Neoadjuvant/Adjuvant STI-571 (Gleevec NSC #716051) for Primary and Recurrent Operable Malignant GIST Expressing the KIT Receptor Tyrosine Kinase (CD117)

  • 6666 - Screening Breast Ultrasound in High-Risk Women

  • 6667 - MRI Screening of the Contralateral Breast in Women with a Recent Diagnosis of Breast Cancer

  • 6668 - Positron Emission Tomography Pre- and Post-treatment Assessment for Locally Advanced Non-small Cell Lung Carcinoma

  • 6673 - Multi-center Feasibility Study of Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma in Cirrhotic Patients

In Analysis:

  • 6651 - Role of Radiology in the Pretreatment Evaluation of Invasive Cervical Cancer

  • 6652 - Digital vs. Film Screen Mammography (DMIST)

  • 6658 - CT-Derived Primary Tumor Volume Measurements in Supraglottic Cancer

  • 6662 - Semi-automated Calculation of Volumes of Enhancing Tumor and Tumor + Edema from Routine MR Images in Patients with Malignant Gliomas

In Development:

  • 6671 - Utility of Preoperative FDG-PET/CT And Ferumoxtran-10 MRI Scanning Prior to Primary Chemoradiation Therapy to Detect Retroperitoneal Lymph Node Metastasis in Patients with Locoregionally Advanced Carcinoma of the Cervix

  • 6672 - Comparison of Preoperative Ferumoxtran-10 Enhanced MRI to conventional MRI in the Detection and Characterization of Pelvic Lymph Nodes in Patients with Bladder Cancer

  • 6674 - A Phase II Multi-Center Study of Focused Ultrasound Ablation of Breast Cancer Under MR Guidance (MRgFUS) and MRI Evaluation of Ablation

  • 6676 - The BEST Trial: A Randomized Phase II Study of VEGF, RAF kinase, mTOR, and EGF-R Targeted Combination Therapy in Advanced Renal Cell Carcinoma

  • 6677 - MR Perfusion and Spectroscopy of newly-identified Intra-axial Mass lesions

  • 6678 - FDG-PET as a Predictive Marker of Tumor Response and Patient Outcome in advanced NSCLC Patients

  • 6679 - FDG-PET/CT in prediction of pathologic response of tumor in patients with localized esophageal cancer who undergo chemotherapy and/or chemoradiation prior to surgical resection