Papandonatos, George

Associate Professor (Research)

Department of Biostatistics
Brown University
Box G-S121-7
121 S. Main Street
Providence, RI 02912
Phone:+1 401 863 9186
Alt. Phone:
Email:gdp@stat.brown.edu


Read George Papandonatos's full Faculty Profile.

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Dr. Papandonatos has research interests in hierarchical modeling of continuous and discrete data, and in population genetics, particularly phenotypes related smoking initiation and progression to nicotine dependence.


BIOGRAPHY


Dr. Papandonatos joined the Department of Community Health at Brown University in 1998, where he now holds an academic appointment as Associate Professor of Biostatistics. He is also affiliated with the Centers for Behavioral & Preventive Medicine at the Miriam Hospital. Since his move to Brown, he has developed extensive collaborations in Behavioral Medicine, in the areas of smoking cessation, physical activity, and weight loss interventions. He has served as project statistician and co-Investigator on 32 funded R01 and U01 projects, and as statistical mentor on 9 career awards in these areas. Additionally, he served as Principal Investigator of the Statistics & Data Management Core of the TTURC-SPORE P50 grant on "Nicotine Dependence: Phenotype, Endophenotype & Contexts" from 1999-2010.
Dr. Papandonatos holds a B.Sc. in Mathematics, Operational Research & Economics from the University of Essex, UK, a Diploma in Statistics from the University of Kent, UK, and a Ph.D. in Statistics from the University of Minnesota (Twin Cities), USA.


INTERESTS


Dr. Papandonatos original research interests lay in the area of Bayesian predictive inference. Through his collaborations with researchers in the area of behavioral medicine, Dr. Papandonatos has more recently developed interests in item response theory models for analyzing nicotine dependence phenotypes, non-linear mixed models for analyzing cortisol response to stress structural equation models for analyzing twin data, and in the conduct of linkage and association studies for examining the genetic determinants of smoking initiation and transition to dependence, and their interaction with environmental factors in a 3-generation sample in New England. Additionally, he has analyzed data from pharmacogenomic studies of bupropion treatment aimed at promoting long-term smoking abstinence and reducing risk of subsequent relapse.
More recently, Dr. Papandonatos has conducted genome wide analyses of SNP markers of obesity-related phenotypes in the Look Ahead trial, a longitudinal trial seeking to identify determinants of weight loss and weight regain.


DEGREES


Ph.D. (Statistics), U of Minnesota, 1994


AWARDS


Not Available


AFFILIATIONS


American Statistical Association Royal Statistical Society International Biometric Society Behavior Genetics Association Society for Behavioral Medicine International Genetic Epidemiology Society Society for Research on Nicotine & Tobacco



FUNDED RESEARCH


"Restraint and attributions" Principal Investigator: Dr. Lorraine Collins Agency: NIAAA/RIA subcontract Type: 1R01 AA07595 Period: April 1, 1997 to August 30, 1998 Study of the use of personal digital assistants (PDA) in recording Ecological Momentary Assessments (EMA) to capture drink-related variables in the natural environment.
"Multilevel Compliance Model of Breast Cancer Treatments" Principal Investigator: Dr. Mary Fennell Agency: NCI Type: 1R01CA074185 Period: January 1, 1998 to December 31, 1999 A project to examine the determinants on non-compliant treatment among a sample of older women with early stage breast cancer from the SEER-Medicare linked databases.
"Immunizing against Tobacco Use in Pediatric Health Care" Principal Investigator: Dr. Raymond Niaura Agency: NIDA/Miriam Hospital Subcontract Type: 1R01 DA012529 Period: October 1, 1998 to August 31, 2004 A longitudinal comparison of two interventions designed to prevent or delay smoking in adolescents.
"Facility Effects on Racial Differences in NH Quality" Principal Investigator: Dr. Mary Fennel Agency: AHRQ Type: 1R01 HS010322 Period: September 30, 1999 to September 29, 2001 An exploration of the interplay of race and facility characteristics in determining the quality of care received by vulnerable populations.
"Smoking Cessation in the Chest Pain Observation Unit" Principal Investigator: Dr. Beth Bock Agency: NHLBI/Miriam Hospital Subcontract Type: 1R01 HL60986 Period: August 1, 1999 to July 31, 2003 A study of the efficacy of a smoking cessation intervention during the 'teachable moment' provided by visits to the chest pain observation unit.
"Innovative Approaches to Disease Prevention through Behavior Change" Principal Investigator: Dr. Belinda Borrelli Agency: NHLBI/Miriam Hospital Subcontract Type: 1R01 HL062165 Period: August 1, 1999 to July 31, 2003 A comparison of two smoking cessation interventions among parents of children with asthma.
"Nicotine Dependence; Risk and Recovery over Generations" Principal Investigator: Dr. David Abrams Agency: NCI/Miriam Hospital Subcontract Type: 1P50 CA084719 Period: September 30, 1999 to September 29, 2004 The major goal of this project is to design and implement (a) studies of trajectories and pathways of smoking initiation and progression to nicotine dependence, and (b) the role of premorbid, comorbid, and dependence factors in lifetime smoking patterns and in trajectories and pathways to smoking cessation.
"Exercise Instruction via Phone or Print" Principal Investigator: Dr. Bess Marcus Agency: NCI/Miriam Hospital Subcontract Type: 1R01 HL64342 Period: October 1, 2000 to September 30, 2004 A longitudinal randomized clinical trial to evaluate the effects of an exercise counseling program delivered by either phone or print as compared to a waiting list control group.
"Smoking Cessation in Emergency Respiratory Patients" Principal Investigator: Dr. Beth Bock Agency: NIH/Miriam Hospital Subcontract Type: 1R01 HL065595 Period: July 1, 2000 to June 30, 2004 A study of the efficacy of a smoking cessation intervention during the 'teachable moment' provided by ER visits of patients with respiratory problems.
"Prenatal Smoking Exposure and Infant Cortisol Reactivity" Principal Investigator: Dr. Laura Stroud Agency: NIDA/Miriam Hospital Subcontract Type: 1R03 DA14394 Period: September 30, 2001 to September 29, 2003 A study of adrenocortical stress reactivity in infants exposed and unexposed to maternal smoking during pregnancy that aims to identify biobehavioral markers for high-risk infants.
"A Longitudinal Study of Hazardous Drivers with Dementia" Principal Investigator: Dr. Brian Ott Agency: NIA/Memorial Hospital Subcontract Type: 1R01 AG1G355 Period: October 1, 2001 to August 31, 2007 A longitudinal study of driving impairment among patients with dementia as it relates to changes in visual perception, visual attention, and executive function over the course of the disease.
"Evaluating Self-Help Programs for Exercise Adoption and Maintenance in Women" Principal Investigator: Dr. Melissa Napolitano Agency: RWJF/Miriam Hospital Subcontract Type: RWJF-044224 Period: February 15, 2002 to February 14, 2005 A randomized clinical trial to compare three self-help programs for exercise adoption and maintenance in terms of their effectiveness of the two programs and to test their public health impact.
"Economic Impact of Tobacco Use Across the Life Span" Principal Investigator: Dr. Charles Neighbors Agency: RWJF/Miriam Hospital Subcontract Type: RWJF-044595 Period: January 15, 2002 to December 14, 2007 An analysis of family-level data to more accurately estimate costs associated with smoking, followed by a separate cost-benefit analysis of a randomized clinical trial of smoking cessation.
"Computerized Physical Activity Promotion in Primary Care" Principal Investigator: Dr. Christopher Sciamanna Agency: NHLBI/Miriam Hospital Subcontract Type: 1R01 HL067005 Period: June 1, 2003 to May 31, 2004 A two-group comparison (6-month treatment, usual-care control) of the effects of computer-generated physical activity reports (patient and physician) on the patients' physical activity and endurance fitness.
"SES, Cardiovascular Health and Health Behaviors in Vietnam Era Male Twins" Principal Investigator: Dr. J.M. McCaffery Agency: NHLBI/Miriam Hospital Subcontract Type: 1R01 HL072819 Period: June 1, 2004 to May 31, 2007 An analysis of genetic and environmental influences on SES, Cardiovascular Health and Health Behaviors in Vietnam Era Male Twins, as well as examination of possible gene-by-environment interactions.
"Physical Activity Promotion in Cancer Follow-Up Care" Principal Investigator: Dr. B. Pinto Agency: ACS/Miriam Hospital Subcontract Type: RSGPH-03-243-01-PBP Period: July 1, 2004 to June 30, 2009 A two-group comparison (brief vs. extended advice) for physical activity among patients that have completed treatment for breast or colorectal cancer.
"Internet and Telephone Treatment for Smoking Cessation" Principal Investigator: Dr. A. Graham Agency: NCI/Georgetown University Type: 1R01 CA104836 Period: August 25, 2004 to May 31, 2010 A comparison of the efficacy and cost-effectiveness of a premium web-based intervention, alone or in conjunction with proactive telephone counseling to access to a non-interactive control website.
"Promoting Physical Activity after Colorectal Cancer" Principal Investigator: Dr. B. Pinto Agency: NCI/Miriam Hospital Subcontract Type: 1R01 CA101770 Period: September 15, 2004 to June 30, 2010 A randomized controlled clinical trial for moderate-intensity physical activity among patients that have completed treatment for breast or colorectal cancer.
"Nicotine Dependence: Phenotype, Endophenotype & Contexts" Principal Investigator: Dr. R. Niaura Agency: NCI/Butler Hospital Subcontract Type: 2P50 CA084719 Period: September 30, 2004 to July 31, 2010 The major goal of this project is to 1) conduct a two-generation family study of genetic/familial influences on lifetime patterns of tobacco use phenotypes and comorbid psychiatric disorders; 2) conduct an endophenotypic study of sib pairs discordant for these tobacco use phenotypes, involving fMRI with nicotine challenge; and 3) examine mediation and moderation of the influence of neighborhood factors on the progression of tobacco use, alcohol, and other drug use in adolescents.
"Maintaining Exercise after Cardiac Rehabilitation" Principal Investigator: Dr. B. Pinto Agency: NHLBI/Miriam Hospital Subcontract Type: 1R01 HL076734 Period: July 1, 2004 to May 31, 2010 A two-group comparison (brief vs. extended advice) for long-term exercise maintenance among patients that have completed a Phase II cardiac rehabilitation program.
"Reducing Ethnic Health Disparities: Motivating HIV+ Latinos to Quit Smoking" Principal Investigator: Dr. R. Niaura Agency: NIDA/Butler Hospital Subcontract Type: 1R01 DA018079 Period: August 5, 2005 to July 31, 2010 A culturally-tailored, motivationally-enhanced smoking cessation intervention for a low-income Latino HIV+ population.
"Prenatal Smoking, Fetal Behavior, and Infant Withdrawal Principal Investigator: Dr. L. Stroud Agency: NCI/Miriam Hospital Subcontract Type: 1R01 DA019558 Period: June 1, 2005 to May 31, 2011 A naturalistic study of the effect of maternal smoking during pregnancy on offspring neurobehavior during the fetal and early neonatal period.
"Achieving Physical Activity Guidelines Through an Enhanced Print Intervention" Principal Investigator: Dr. Bess Marcus Agency: NCI/Miriam Hospital Subcontract Type: 2R01 HL64342 Period: April 1, 2006 to October 31, 2010 A randomized controlled clinical trial to determine the differential effect of the print-based individually-tailored intervention used in the parent trial vs. an enhanced print-based intervention on physical activity.
"Naturalistic Assessment of the driving ability of cognitively impaired elders" Principal Investigator: Dr. Brian Ott Agency: NIA/RIH subcontract Type: 2R01 AG1G355 Period: April 1, 2007 to March 31, 2011 A study to evaluate the driving ability of cognitively impaired elders in both their natural environment and via a road test.
"Maternal Depression, Placental HPA Regulation, & Fetal/Neonatal Stress Response" Principal Investigator: Laura Stroud Agency: NIMH/Miriam Hospital Subcontract Type: 1R01 MH079153 Period: September 1, 2007 to July 31, 2012 A naturalistic study of the effect of maternal depression during pregnancy on offspring neurobehavior during the fetal and early neonatal period.
"Psychosocial Telephone Intervention for Dementia Caregiver Burden" Principal Investigator: Dr. G. Tremont Agency: NINR/RI Hospital Subcontract Type: 1RO1 NR010559 Period: September 28, 2007 to May 31, 2012 A study to test the efficacy of a multicomponent family-based telephone intervention in reducing levels of depression and anxiety, feelings of burden and stress, and family functioning for dementia caregivers.
"Reducing violence against women with alcoholic partners" Principal Investigator: Dr. Robert Rychtarik Agency: NIAAA/SUNY-RIA subcontract Type: 1R01 AA0167991 Period: May 1, 2008 to April, 2013 A study to evaluate the effectiveness of a Coping Skills Training program with both a self-help treatment arm and a delayed-treatment control group.
"Community Volunteers Promoting Physical Activity Among Cancer Survivors" Principal Investigator: Dr. B. Pinto Agency: NCI/Miriam Hospital Subcontract Type: 1R01 AA0167991 Period: January 1, 2009 to November 30, 2012 A longitudinal assessment of changes in distress, coping, and quality of life of cancer patients required to attend followup visits for continued surveillance.
"Gene x Behavior Interaction in the Look AHEAD study" Principal Investigators: Drs. R. Wing & J. McCaffery Agency: OBSSR/NIDDK/Miriam Hospital Subcontract Type: 3U01-DK056992-11S1 Period: January 1, 2009 to November 30, 2012 A study to identify genes that interact with behavioral lifestyle modification interventions in predicting weight loss at the 12-month follow-up of the Look AHEAD sample.
"Increasing Sleep Duration: A novel approach to weight control" Principal Investigator: Dr. R. Wing Agency: NCI/Miriam Hospital Subcontract Type: 1U01 CA150387 Period: September 28, 2009 to August 31, 2014 A comparison of weight-related outcomes among subjects assigned to an increased sleep duration modification of standard weight-loss programs "Using a State-wide Initiative to Disseminate Effective Behavioral Weight Loss" Principal Investigator: Dr. Rena Wing Agency: NIDDK/The Miriam Hospital Subcontract Type: 1R18 DK083248 Period: July 1, 2010 to June 30, 2014 A comparison of weight-related outcomes among subjects assigned to an Enhanced version of the Shape-Up RI program rather than a Standard arm.
"Genetic and Behavioral Effects on High-Density Lipoprotein: The Look AHEAD Study" Principal Investigator: Dr. Jeanne McCaffery Agency: NIDDK/The Miriam Hospital Subcontract Type 1R01 DK090043 Period: March 1, 2011 to February 28th, 2014 Fitting gene by treatment interaction models for HDL outcomes in a randomized clinical trial comparing behavioral therapy to a control condition, and exploring potential mediation of these interactions via diet and exercise.
"Acceptance-Based Behavioral Intervention for Weight Loss: A Randomized Trial" Principal Investigator: Dr. Rena Wing Agency: NIDDK/The Miriam Hospital Subcontract Type: 1R01 DK087704 Period: April 15, 2011 to March 31, 2015 Compare weight-regain outcomes among subjects assigned to an acceptance-based behavioral intervention, versus those enrolled in a standard care weight-loss program.
"Multiple Sclerosis: Prevalence & Social Functioning by Disease, Duration, and Subtype." Principal Investigator: Dr. Stephen Buka Agency: National Multiple Sclerosis Society Type: RG428IL2 Period: October 1, 2011 to September 30, 2013. The goal of this study is to estimate the prevalence and incidence of MS within the state of RI, and to describe how three sub-domains of social functioning vary in relation to disease duration and subtype.
"Improving Adherence to Web-based Cessation Programs: A Social Network Approach" Principal Investigator: Dr. Amanda Graham Agency: NCI/Legacy Foundation Subcontract Type: 1R01 CA1555489 Period: October 1, 2012 to April 30, 2016 Examine the extent to which online social support interacts with nicotine replacement therapy in improving smoking abstinence in a randomized clinical trial with a 2x2 factorial design.
"Behavioral Weight Loss as a Treatment for Migraine in Obese Women" Principal Investigator: Dr. Dale Bond Agency: NINDS/The Miriam Hospital Type: 1R01 NS077925 Period: July 1, 2012 to June 30, 2016 Compare migraine longitudinal outcomes among subjects assigned to a behavioral weight loss program (BWL) versus a migraine health-education control (MHEC) group.
"A Randomized Trial Testing Lay Health Coaches for Obesity Treatment " Principal Investigator: Dr. Patricia Leahey Agency: NIDDK/The Miriam Hospital Type: R01 1DK095771 Period: December 1, 2012 to November 30, 2017 A randomized clinical trial examining the impact of social support on weight-related outcomes.
"LIVE SMART: Smartphone Intervention for Weight Control" Principal Investigator: Dr. Graham Thomas Agency: NIDDK/The Miriam Hospital Type: R01 1DK095771 Period: September 1, 2012 to August 31, 2016. An RCT to compare weight-related longitudinal outcomes among subjects assigned to a standard behavioral weight loss program, one delivered via on smart-phone applications and the other face-to-face.



Curriculum Vitae


Download George Papandonatos's Curriculum Vitae in PDF Format


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