Gatsonis, Constantine

Henry Ledyard Goddard University Professor of Biostatistics

Department of Biostatistics and Center for Statistical Sciences
Brown University
Box G-S121-7
121 S. Main Street
Providence, RI 02912
Phone:+1 401 863 9183
Alt. Phone:
Email:gatsonis@stat.brown.edu


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Constantine Gatsonis has research interests in Bayesian inference and its applications to problems in biostatistics, medical technology evaluation with emphasis on the clinical evaluation of diagnostic imaging and biomarkers, bioinformatics, and methodologic aspects of health services and outcomes research.


BIOGRAPHY


Constantine Gatsonis, PhD, is Henry Ledyard Goddard University Professor of Biostatistics and Chair of the Department of Biostatistics at Brown. He joined the faculty 1995 and became the founding Director of the Center for Statistical Sciences. Dr. Gatsonis is a leading authority on the design and analysis of clinical trials of diagnostic and screening modalities and has extensive involvement in methodologic research in medical technology assessment and in health services and outcomes research. He is Group Statistician of the American College of Radiology Imaging Network (ACRIN), a NCI funded collaborative group conducting multi-center studies of diagnostic imaging and image-guided therapy for cancer. In his ACRIN work, Dr Gatsonis is the chief statistician of the Digital Mammography Imaging Screening Trial (a national study comparing digital to film mammography) and is also the chief statistician for ACRIN's arm of the National Lung Screening Trial (NLST). Dr Gatsonis was the lead statistician of the International Breast MRI Consortium and of the Radiologic Diagnostic Oncology Group (RDOG).
Dr. Gatsonis has served on numerous review and advisory panels, including the HSDG Study Section of the Agency for Health Care Policy Research, panels of the Center for Devices and Radiological Health of FDA, the Commission of Technology Assessment of the American College of Radiology, Data Safety and Monitoring Boards for NINDS and the VA, the Immunization Safety Review Committee of the Institute of Medicine. He is a member of the steering group of the STARD project (Standards for Reporting of Diagnostic Accuracy), which recently published the first comprehensive checklist for reporting the results of diagnostic test evaluations. He is also co-convenor of the Screening and Diagnostic Tests Methods Working Group of the Cochrane Collaboration and a member of the steering group of the Cochrane Diagnostic Reviews initiative, which is developing the methodologic and organizational infrastructure for the inclusion of systematic reviews of diagnostic accuracy in the Cochrane Library.
Dr. Gatsonis is the founding editor-in-chief of Health Services and Outcomes Research Methodology and serves as a deputy editor of Academic Radiology and a member of the editorial board of Clinical Trials . Previous editorial experience includes membership of the editorial board of Statistics in Medicine , and Medical Decision Making .
Dr Gatsonis was elected fellow of the American Statistical Association and the Association for Health Services Research.


INTERESTS


Statistical methods for Diagnostic Test Evaluation
Dr. Gatsonis' current and recently completed work in this area addresses problems arising in the design and analysis of clinical studies of diagnostic modalities. Topics include, Bayesian methods for the design of multi-reader, multi-modality studies (with Fei Wang, Boston University), Two-phase designs for estimating and comparing ROC curves (with Mei –Hsiu Chen, Brown University), Group-sequential designs for ROC analysis (with X-H (Andrew) Zhou, University of Washington), Studies of the predictive value of diagnostic tests (with Shang Ying Shiu, Brown University), Bayesian methods for equivalence studies (with Kostas Kalogeropoulos), Designs of studies evaluating the outcomes of diagnostic tests (with Bo Lu, Ohio State University), and Methods for the evaluation of imaging biomarkers.
Multi-center clinical studies of diagnostic and screening tests
Since 1999 Dr. Gatsonis has been Group Statistician of the American College of Radiology Imaging Network (ACRIN), a NCI funded collaborative group conducting multi-center studies of diagnostic imaging and image-guided therapy for cancer (http://stat.brown.edu/section/ACRIN/ and www.acrin.org ). In addition to his broader scientific and managerial role in ACRIN, he is the lead statistician in several of the network's studies. In particular, he is the lead statistician of the Digital Mammography Imaging Screening Trial (DMIST—a national study comparing digital to film mammography) and also the lead statistician for ACRIN's arm of the National Lung Screening Trial (NLST—a national study comparing helical CT to x-ray in screening for lung cancer).
Before the launching of ACRIN, he was the lead statistician of the Radiologic Diagnostic Oncology Group (RDOG) , which pioneered multi-center studies in radiology, and of the International Breast MRI Consortium.
Meta-analysis of diagnostic accuracy studies
Dr. Gatsonis' methodologic work in this area introduced and developed the Hierarchical Summary ROC (HSORC) approach to meta-analysis of studies reporting estimates of the accuracy of tests. A primer for systematic reviews of diagnostic accuracy (co-authored with Prashni Paliwal, Yale University) will appear in AJR shortly.
He is co-convenor of the Screening and Diagnostic Test Methods Working Group of the Cochrane Collaboration ( http://www.cochrane.org/sadt/index.htm ) and a member of the Steering Group which oversees the development of the handbook and infrastructure necessary for launching the Cochrane Diagnostic Reviews. He serves as a co-editor of the Handbook and, together with Petra Macaskill (University of Sydney), a lead author of the chapter on statistical methods.


DEGREES


PhD, Cornell University


AWARDS


Phi Beta Kappa (1976) National Research Service Award, National Institute of Mental Health (1986-1988) Fellow, Association for Health Services Research (1997) Fellow, American Statistical Association (1998) Spinoza Visiting Professor, Academic Medical Center, University of Amsterdam, Netherlands (June 2003)


AFFILIATIONS


Recent Professional Activities a. Review and advisory panels National Academy of Sciences, Committee on Identifying the Needs of the Forensic Sciences Community (Co-Chair) (2007-2008)
Institute of Medicine, Immunization Safety Review Committee (2001-2004)
Special Review Panel for CISNET applications (Chair), NCI (2000, 2005)
Center for Devices & Radiological Health, Food & Drug Administration, Consultant/Ad hoc Panel Member (1997-2003)
Commission on Technology Assessment, American College of Radiology (1997-2003)
Data Safety and Monitoring Board, NINDS (1998-2002)
Technical Expert Panels, HCFA/CMS (1999-2004)
b. Professional leadership and service
Diagnostic and Screening Test Methods Working Group Cochrane Collaboration (Convenor since 1997)
Steering Group, Cochrane Diagnostic Reviews Initiative, Co-Editor of CDR Handbook (2003-present)
RSNA Clinical Trials Methodology Workshop, Co-director (2005-present)
Steering Committee, STARD (Standards for Reporting of Diagnostic Accuracy Project (2000-present)
Scientific Program Committee, Eastern Mediterranean Region of International Biometric Society (2002-present)
NCI-sponsored Image Guided Intervention Trial Design Methods Workshop, Co-chair (February 2004)
Clinical Evidence Diagnosis Advisory Group, British Medical Journal (Summer 2004)
Case Studies in Bayesian Statistics , Biannual Workshop Series, Carnegie Mellon University (Co-organizer since 1991)
Program and Advisory Committees, International Conference on Health Policy Research (1997-2004)
c. Editorial positions Founding Editor in Chief: Health Services and Outcomes Research Methodology (1998-present)
Associate Editor: Clinical Trials (2003-present) Bayesian Analysis (2005-present) Annals of Applied Statistics (2008 -)
Editorial Boards: Academic Radiology (1996-present) Statistics in Medicine (1996-2005) Medical Decision Making (1999-2002)



FUNDED RESEARCH


Currently funded projects Biostatistics and Data Management Center of the American College of Radiology Imaging Network (ACRIN) Funded since 1999 by the National Cancer Institute. See Research for description of ACRIN. Average annual total for primary grant and supplements: $3,500,000.
Selected past funded projects
Multi-Center Clinical Evaluation of MRI in Breast Cancer NCI funding period: 09/05/1997-06/30/2003 The International Breast MRI Consortium (IBMC) was an international, NCI-funded consortium organized to evaluate the role of MRI in breast cancer. The consortium conducted two multi-center studies, a large, prospective evaluation of breast MRI for women with a suspicious mammogram, and a pilot study of the potential of breast MRI in screening women at high risk for breast cancer. The Biostatistics and Data Management Center of IBMC was directed by Constantine Gatsonis and was operated jointly by the Brown University Center for Statistical Sciences and the ACR's Data Management Center in Philadelphia.
Staging Breast Cancer with Positron Emission Tomography University of Michigan Subcontract, NCI funding period: 09/30/1995-07/31/2001 This subcontract provided support for the Biostatistics Center of a multi-center prospective trial to assess the accuracy of PET in staging patients with newly diagnosed breast carcinoma.


WEB LINKS



Curriculum Vitae


Download Constantine Gatsonis's Curriculum Vitae in PDF Format


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